Safety of Hepatitis B Vaccine
β Scribed by Fields, H. A.; Mahoney, F. J.; Margolis, H. S.
- Book ID
- 121156104
- Publisher
- American Association for the Advancement of Science
- Year
- 1996
- Tongue
- English
- Weight
- 571 KB
- Volume
- 272
- Category
- Article
- ISSN
- 0036-8075
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π SIMILAR VOLUMES
A hepatitis B vaccine produced in yeast by recombinant DNA technology was evaluated using 5-micrograms and 10-micrograms doses in a randomized trial lasting 7 months in 110 male armed forces recruits aged 17-19 years. Results were compared to those of an identical trial of a plasma-derived vaccine.
Hepatitis B vaccines are highly effective and safe and have been incorporated into national immunization programs in over 150 countries. The major humoral immune response is to the common a determinant of the surface antigen protein of the virus. Approximately 5-10% of healthy immunocompetent subjec