Safety of gadodiamide injection in two different age groups

✍ Scribed by Barry Högström; Doris T. Kristoffersen; Bjørg Lundby; Marit G. Svaland

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 333 KB
• Volume: 6
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880060145

✦ Synopsis

A meta-analyses was performed to evaluate the safety of gadodiamide injection (OM-MSCANa) for magnetic resonance imaging in two different age groups (< 65 years: 2 65 years). Data on Vital signs, ters, and subjectively experienced adverse events were reviewed for 734 patients included in 19 European Phase II and IJI trials with gadodiamide injection (0. l mmol/kg body weight or 0.3 mmol/kg body weight) used in magnetic resonance imaging. One hundred sixty-four patients were 66 years of age or older. No statistically significant differences were shown between this population and the population younger than 65 yeears of age with respect to tory parameters. A total of 48 adverse events, discomfort excluded, were reported, with no significant difference in frequency between the two age groups. Injection-associated (P = .0025) more frequent in the younger (9.2%) than in the older group (2.5%). Gadodiamide injection is in conclusion a safe contrast medium in older as well as in younger patients. clinical laboratory paramevital signs or clinical laboradiscomfort was signiflcantly Index ternu: Contrast media -Contrast media, age -Contrast media. adverse reactions -Contrast media, meta-analyses * Gadolinium * Gadodiamide Magnetic resonance FIR)