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Safety Improvement of a Grignard Reaction Using On-Line NIR Monitoring

✍ Scribed by Wiss, Jacques; Länzlinger, Markus; Wermuth, Markus

Book ID
120461364
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
299 KB
Volume
9
Category
Article
ISSN
1083-6160

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Near infrared (NIR) spectroscopy has been used in a noninvasively mode to develop qualitative and quantitative methods for the monitoring of a wet granulation process. The formulation contained API (10%w/w) and microcrystalline cellulose and maize starch as main excipients. NIR spectra have been acq