A Phase I study of interferon alfa-2a was conducted in 20 patients with disseminated cancer to establish the relationship between dose and interferon-related side effects. Fever was the most common side effect, and was not doserelated. Other side effects not related to dose included flu-like symptom
Safety and tolerance of recombinant interferon alfa-2a (roferon®-A) in Cancer Patients
✍ Scribed by Gary J. Jones; Loretta M. Itri
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 748 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0008-543X
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This is a review of the data on the safety and tolerance of interferon alfa-2a in the treatment of cancer patients and is particularly aimed at patient care. Since 1981, interferon alfa-2a prepared from human sources has been administered t o over 2500 cancer patients and 2500 patients with viral di
Background. Both recombinant in1 erferon alfa and interleukin-2 (IL-2) have been shown to lave some activity as single agents in metastatic renal cj !I1 cancer (RCC), although their activity is minimal in mo -e common solid tumors. Recent preclinical studies hav ? suggested that the combination of t