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Safety and tolerability of rosiglitazone XR in a randomised, placebo-controlled study in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease

✍ Scribed by Marina Zvartau-Hind; Claire Alderton; Sally Ritchie; Ann Saunders; Michael Irizarry; Suzanne Craft; Gary Landreth; Ülla Linnamägi; Sharon Sawchak; Michael Gold


Book ID
118464882
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
169 KB
Volume
5
Category
Article
ISSN
1552-5260

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Background. Metrifonate is a long-lasting acetylcholinesterase inhibitor being developed for the symptomatic treatment of Alzheimer's disease (AD). Objectives. This study compared the ecacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate AD, over a 26-week tre