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Safety and tolerability of high-dose intravenous esomeprazole for prevention of peptic ulcer rebleeding

✍ Scribed by Ernst J. Kuipers; Joseph J. Y. Sung; Alan Barkun; Joachim Mössner; Dennis Jensen; Robert Stuart; James Y. W. Lau; Henrik Ahlbom; Tore Lind; Jan Kilhamn

Book ID: 107648717
Publisher: Springer Healthcare Communications
Year: 2010
Tongue: English
Weight: 549 KB
Volume: 28
Category: Article
ISSN: 0741-238X
DOI: 10.1007/s12325-010-0095-5

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## Abstract ## Background Rebleeding from peptic ulcers is a major contributor to death. This study compared standard (40-mg intravenous infusion of omeprazole once daily for 3 days) and high-dose (80-mg bolus of omeprazole followed by 8-mg/h infusion for 72 h) in reducing the rebleeding rate (pri