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SAFB1 interacts with and suppresses the transcriptional activity of p53

✍ Scribed by Philippos Peidis; Nikolaos Voukkalis; Eleni Aggelidou; Eleni Georgatsou; Margarita Hadzopoulou-Cladaras; Robert E. Scott; Eleni Nikolakaki; Thomas Giannakouros

Book ID
113622342
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
559 KB
Volume
585
Category
Article
ISSN
0014-5793

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SIRT1 interacts with p73 and suppresses
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## Abstract The tumor suppressor p53‐related p73 shares significant amino‐acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA‐binding sites and activates p53‐responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their