Saccadic latency in hepatic encephalopathy: a pilot study
β Scribed by Florian Krismer; Jonathan C. P. Roos; Melanie Schranz; Ivo W. Graziadei; Sergei Mechtcheriakov; Wolfgang Vogel; R. H. S. Carpenter; Heinz Zoller
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 308 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-7490
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Hepatic encephalopathy (HE) results from acute or chronic liver dysfunction and is associated with hyperammonemia. Ammonium ions penetrate from blood to brain, where they form glutamine (Gln) in the reaction with glutamate catalyzed by an astrogliaβspecific enzyme, glutamine synthetase
The GABAergic agonist, muscimol, and antagonists, picrotoxin and bicuculline, have been studied in rats with chronic portacaval shunts and in rats developing hepatic encephalopathy after massive ischemic necrosis due to hepatic artery ligation within 48 hr of a portacaval shunt. After the chronic po