✦ LIBER ✦

Sa.51. The Molecular Basis of Functional Stability of Regulatory T-Cells: The Memory of TH Cells for IL-10 Expression Is Conditional Unless the Gene Is Imprinted by Gata-3

✍ Scribed by Hyun-Dong Chang; Christina Helbig; Jun Dong; Maurus De La Rosa; Susan Brandenburg; Uwe Niesner; Alexander Scheffold; Andreas Thiel; Andreas Radbruch

Book ID: 113539221
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 53 KB
Volume: 119
Category: Article
ISSN: 1090-2341
DOI: 10.1016/j.clim.2006.04.283

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Expression of IL-10 in Th memory lymphoc

Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3

✍ Hyun-Dong Chang; Christina Helbig; Lars Tykocinski; Stephan Kreher; Juliana Koec 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 392 KB

## Abstract In Th1 and Th2 memory lymphocytes, the genes for the cytokines interleukin (IL)‐4 and interferon‐γ (IFN‐γ) are imprinted for expression upon restimulation. This cytokine memory is based on expression of the transcription factors T‐bet for IFN‐γ, and GATA‐3 for IL‐4, and epigenetic modif