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Sa2026 Thiopurine Methyltransferase, Inosine Triphosphate Pyrophosphohydrolase and Glutathione S Transferases Genotypes Among Patients With Inflammatory Bowel Disease Treated With Azathioprine

โœ Scribed by Aljudaibi, Bandar; Schwarz, Ute I.; Kim, Richard B.; Dresser, George K.; Ponich, Terry P.; Chande, Nilesh; Gregor, James C.; Huda, Noureen


Book ID
122873059
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
71 KB
Volume
142
Category
Article
ISSN
0016-5085

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## Background: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-s-methyltransferase (tpmt) deficiency. azathioprine is known to induce glutathione depletion and consumption of glutathione is greate

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