S5.13 Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor

Acidic and basic fibroblast growth facto

Acidic and basic fibroblast growth factor bind with differing affinity to the same heparan sulfate proteoglycan on BALB/c 3T3 cells: Implications for potentiation of growth factor action by heparin

✍ Kathryn J. Brown; Ian A. Hendry; Christopher R. Parish 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 806 KB

Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of