✦ LIBER ✦

S3-03-02: Transgenic mice with the arctic APP mutation as animal models of Alzheimer's disease

✍ Scribed by Lars Nilsson

Book ID: 118463999
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 55 KB
Volume: 4
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2008.05.386

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## Abstract Transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP[V717I]) in neurons develop amyloid plaques in the brain, thus demonstrating the most prominent neuropathological hallmark of Alzheimer's disease. In vivo 3D __T__~2~\*‐weighted MRI on these mice (24