S.26.03 A PET-study of extrastriatal D2-dopamine receptors
β Scribed by L. Farde
- Book ID
- 118599732
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 301 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0924-977X
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11 C]raclopride binding to D2 dopamine receptors in the striatum is sensitive to drug-induced changes of endogenous dopamine concentration. We recently developed the new radioligand [ 11 C]FLB 457, which is suitable for positron emission tomography (PET) studies of extrastriatal D2 dopamine recepto
The selective D2-dopamine receptor antagonist raclopride and its pharmacologically inactive (R)-enantiomer FLB472 were labelled with 11C and used in a study with positron emission tomography to examine the stereoselectivity of 11C-raclopride binding to central D2-dopamine receptors in three healthy