𝔖 Bobbio Scriptorium
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S.19.02 IGF-1 signaling: Role in neuroprotection and major depression

✍ Scribed by I. Torres-Aleman; J.L. Trejo; E. Garcia-Galloway; E. Carro


Book ID
119576712
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
294 KB
Volume
13
Category
Article
ISSN
0924-977X

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## Abstract Overexpression of human IGF‐1 with the bovine keratin 5 (BK5) promoter (BK5.IGF‐1 transgenic mice) induces persistent epidermal hyperplasia and leads to spontaneous skin tumor formation. In previous work, PI3K and Akt activities were found to be elevated in the epidermis of BK5.IGF‐1 tr