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S1685 PAK1 Interacts with β-Catenin and Is Required for the Regulation of the β-Catenin Signalling Pathway By Gastrins

✍ Scribed by He, Hong; Shulkes, Arthur; Baldwin, Graham S.


Book ID
123533456
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
116 KB
Volume
134
Category
Article
ISSN
0016-5085

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β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the underlying mechanism of this change is unknown. It has been demonstrated that