S1676 Transgenic Overexpression of TGFβ1 Does Not Affect Development of Small Intestinal Adenomas in APCΔ580 Mice

Impairment of mammary lobular developmen

Impairment of mammary lobular development induced by expression of TGFβ1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice

✍ Valeria Buggiano; Carolina Schere-Levy; Keiji Abe; Silvia Vanzulli; Isabel Piazz 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 551 KB

It has previously been shown that transgenic female mice expressing TGF␤1 under control of regulatory elements of the whey-acidic protein (WAP) gene were unable to lactate. This was due to the increased apoptosis of the cells committed to the lobular-lactogenic phenotype. Our goal was to determine w