✦ LIBER ✦
(S)-(–)-α,α-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography
✍ Scribed by Benedetto Natalini; Roccaldo Sardella; Antonio Macchiarulo; Serena Natalini; Roberto Pellicciari
- Book ID
- 102924557
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 840 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1615-9306
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A dynamic coating of the RP‐18 carbon chain layers with the new chiral selector (S)‐(–)‐α,α‐di(2‐naphthyl)‐2‐pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure‐property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron‐donating groups in the side chain of the chiral selector to the mechanism of chiral recognition.