S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo
✍ Scribed by Pekka Rauhala; K. Parameswarannay Mohanakumar; Istvan Sziraki; Anya M.-Y. Lin; Chuang C. Chiueh
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 340 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0887-4476
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✦ Synopsis
Intranigral infusion of ferrous citrate (4.2 nmol) induced an acute lipid peroxidation in the substantia nigra and a chronic dopamine depletion in the striatum of rat nigrostriatal system. Coinfusion of 8.4 nmol nitric oxide donors such as S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) or nitric oxide (-2 nmol) protected nigrostriatal neurons against iron-induced lipid peroxidation and associated oxidative injury. However, sodium nitroprusside (SNP, 8.4 nmol) augmented dopamine depletion caused by ferrous citrate because SNP is a ferricyanide complex. The present in vivo results indicate that nitric oxide and S-nitrosothiols are antioxidants which can protect brain dopamine neurons against oxidant stressldamage.