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S-mephenytoin 4-hydroxylation in older Americans

✍ Scribed by B. G. Pollock; J. M. Perel; M. Kirshner; L. P. Altieri; A. L. Yeager; C. F. Reynolds

Publisher
Springer
Year
1991
Tongue
English
Weight
242 KB
Volume
40
Category
Article
ISSN
0031-6970

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✦ Synopsis

To examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75.4). Ten (6.7%) were identified as categorically slow metabolizers (S:R ratios greater than or equal to .95). This increased incidence of slow metabolizers was accounted for by a significant and previously unreported, increased proportion of slow metabolizers among the black (18.5%) as compared to the white subjects (4.1%) (P = .017). There was no relationship found between S:R ratios and age or creatinine clearance.

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