(S)-Dihydrooroxylin A in human urine following oral administration of the traditional Chinese medicines: Daisaiko-to and Shosaiko-to

✍ Scribed by Chuan Li; Masato Homma; Naoki Ohkura; Kitaro Oka

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 200 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00103-1

✦ Synopsis

Dihydrooroxylin A was isolated and characterized from human urine collected after oral administration of traditional Chinese medicines, Daisaiko-to and Shosaiko-to (Dachaihu-tang and Xiaochaihu-tang in Chinese, respectively). Spectroscopic data (UV, CD, I H NMR and MS) and chiral HPLC analysis revealed that this compound had the S-configuration (80% ee). This is the first example of stereoselective hydrogenation of a substituted flavone into its corresponding flavanone in the human body.