S-Alkylation en série hétérocyclique par catalyse par transfert de phase: thioalkyl-2-thiazoles, thioalkyl-2-Δ-4-thiazolines et thioalkyl-2-benzothiazoles

✍ Scribed by Henri J. M. Dou; Parina Hassanaly; Jacky Kister; Gaston Vernin; Jacques Metzger

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: German
• Weight: 317 KB
• Volume: 61
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19780610842

✦ Synopsis

S‐Alkylation in heterocyclic serie by phase transfer catalysis: 2‐alkylthiothiazoles, 2‐alkylthio‐Δ‐4‐thiazolines and 2‐alkylthiobenzothiazoles

Some Δ‐4‐thiazoline‐, thiazolidine‐, and benzothiazoline‐2‐thiones have been S‐alkylated by phase transfer catalysis; yields averaged 80 to 90%. With halogenated heterocyclic compounds of poor reactivity, the main reaction consisted in a dequaternization of the catalyst by the thiones acting as nucleophiles.