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S-Adenosylmethionine reduces bile acid-induced apoptosis in primary rat hepatocytes by preventing glutathione depletion

โœ Scribed by Benz, C.; Breitkreutz, R.; Kloeters-Plachky, P.; Rudolph, G.; Sauer, P.; Stremmel, W.; Stiehl, A.

Book ID
122546111
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
361 KB
Volume
114
Category
Article
ISSN
0016-5085

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We have previously reported that transforming growth factor-beta (TGF-beta) induces apoptosis in fetal hepatocytes in primary culture. This effect was found to be associated with an increase in intracellular reactive oxygen species (ROS) and a lowering of total cellular reduced glutathione (GSH). In