Because S-adenosylmethionine promotes synthesis of hepatic glutathione in chronic liver disease and is well tolerated in man, we investigated its use as an antidote to acetaminophen hepatotoxicity in two mouse models. In C57Bl6 mice, deaths were abolished by S-adenosylmethionine given within 1 hr of
S-adenosylmethionine protects against acetaminophen-induced hepatotoxicity
β Scribed by Song, Zhenyuan; Chen, Theresa; McClain, Craig
- Book ID
- 122882504
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 508 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We previously reported that liver natural killer (NK) and NKT cells play a critical role in mouse model of acetaminophen (APAP)-induced liver injury by producing interferon gamma (IFN-gamma) and modulating chemokine production and subsequent recruitment of neutrophils into the liver. In this report,
The reactive oxygen species-sensitive transcription nuclear factor-B (NF-B) plays a pivotal role in the development of acetaminophen (APAP) hepatotoxicity. We investigated the efficacy of a diverse series of antioxidants in preventing APAP-induced hepatotoxicity. BALB/c mice were divided into four g