### 9.1. 90) (5)-Norcoclaurine-I-carboxylic acid (5) and the derived dihydroisoquinolinone 6 (present as quinonemethide 6a at pH 7) afforded, on methylation with I4C-labeled S-adenosyl-L-methionine in the presence of mammalian catechol 0 methyitransferase, exclusively the 7-0-methylated congeners 7
✦ LIBER ✦
S-adenosyl-l-methionine: Anol-O-methyltransferase activity in organ cultures of Pimpinella anisum
✍ Scribed by Birgitt Kemmerer; Jürgen Reichling
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 447 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0031-9422
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## Abstract __O__‐Methylation of the optically active 3′‐hydroxycoclaurines 3a and 3b and of the __N__‐methylated analogs 5a,b with __S__‐adenosyl‐L‐[__methyl__‐^14^C]methionine in presence of mammalian COMT was investigated __in vitro.__ The __N__‐unsubstituted (1__S__)‐ and (1__R__ )‐isomers 3a a