S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis

Alterations in the expression of the cel

Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma : Relation to p27Kip1 and its Ubiquitin Ligase Subunit, S Phase Kinase Protein 2

✍ Ma'anit Shapira; Ofer Ben-Izhak; Bishara Bishara; Boris Futerman; Ira Minkov; Mi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 2 views

## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio