Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

✍ Scribed by Ulrika Andersson; Estera S. Dey; Cecilia Holm; Eva Degerman

• Book ID: 102515858
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 154 KB
• Volume: 55
• Category: Article
• ISSN: 1613-4125
• DOI: 10.1002/mnfr.201100231

✦ Synopsis

Abstract

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone‐sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine‐stimulated lipolysis in 3T3‐L1 adipocytes. Furthermore, phosphorylation of hormone‐sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.