Ryanodine: its possible mechanism of action in the caffeine-sensitive calcium store of smooth muscle
โ Scribed by Tetsuhiro Hisayama; Issei Takayanagi
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 619 KB
- Volume
- 412
- Category
- Article
- ISSN
- 0031-6768
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๐ SIMILAR VOLUMES
The patch-clamp method has been used to investigate the action of caffeine on the calcium current (Ic,) in single isolated smooth muscle cells of the guineapig ileum. Caffeine (10 mM) substantially inhibited Ic,. This effect occurred in a biphasic manner and it was not due either to activation of ad
1 Diadenosine polyphosphates (Ap n As, n ฯญ 2 to 6 phosphate groups) activate P2-type cell-surface adenine nucleotide purinoreceptors, increase the influx of calcium into neural cells, and modulate the binding of ryanodine to ryanodine receptor-regulated intracellular calcium release channels. In thi