Parkinson's disease is a neurodegenerative disease that is consequent to the loss of brain dopamine (DA) cells. These abnormalities are thought, in part, to be a manifestation of increased free radical production during the metabolism of catecholamines. The antiapoptic agent, bcl-2, has been shown t
✦ LIBER ✦
Ruthenium–Porphyrin Complexes Induce Apoptosis by Inhibiting the Generation of Intracellular Reactive Oxygen Species in the Human Hepatoma Cell Line (HepG2)
✍ Scribed by Yanan Liu; Xiaonian Zhang; Rong Zhang; Tianfeng Chen; Yum-Shing Wong; Jie Liu; Wen-Jie Zheng
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 492 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-1948
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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF