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Ruthenium-Catalyzed Intramolecular Homo-Diels−Alder Reaction of Alkyne-Tethered Norbornadienes. An Entry to Fused Angular Triquinanes

✍ Scribed by Tenaglia, Alphonse; Gaillard, Sylvain


Book ID
118046663
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
100 KB
Volume
9
Category
Article
ISSN
1523-7060

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We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to efficiently form highly substituted hexahydroisoindole ring systems on Wang resin. This approach was used to prepare a 4200 membered combinatorial library.