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RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression

✍ Scribed by Manish Mani Subramaniam; Jason Yongsheng Chan; Richie Soong; Kosei Ito; Yoshiaki Ito; Khay Guan Yeoh; Manuel Salto-Tellez; Thomas Choudary Putti

Publisher: Springer US
Year: 2008
Tongue: English
Weight: 583 KB
Volume: 113
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-008-9917-4

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## Abstract Bone morphogenic proteins (BMPs) are members of the TGFB growth factor superfamily with well‐described functions in bone formation. Although disrupted BMP signalling in tumor development has more recently been investigated, a role for BMP3 in colorectal cancer (CRC) has remained largely