Mammalian Runt-domain-containing factors are structurally and functionally similar and have essential roles in hematopoiesis and osteogenesis. These factors can act as either positive or negative transcriptional regulators of tissue-specific genes whose promoters or enhancers contain the consensus R
β¦ LIBER β¦
Runt domains take the lead in hematopoiesis and osteogenesis
β Scribed by Werner, Milton H.; Shigesada, Katsuya; Ito, Yoshiaki
- Book ID
- 109827261
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 994 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/70920
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## Abstract Our previous studies suggest that lack of __RUNX3__ function is causally related to the genesis and progression of human gastric cancer, but potential roles of other members of the RUNX family genes have not yet been reported. We examined the expression of 3 Runtβrelated (RUNX) genes, _