Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

✍ Scribed by Jun-Ting Fan; Yi-Shan Chen; Wen-Yan Xu; Liangcheng Du; Guang-Zhi Zeng; Yu-Mei Zhang; Jia Su; Yan Li; Ning-Hua Tan

• Book ID: 104098093
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 444 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.07.066

✦ Synopsis

Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-c-induced RAW 264.7 murine macrophages.