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Rubia cordifolia extract inhibits cell proliferation in A-431 cells

✍ Scribed by Yamini B. Tripathi; Shivendra D. Shukla

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
83 KB
Volume
12
Category
Article
ISSN
0951-418X

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✦ Synopsis

The antiproliferative property of Rubia cordifolia (Rubiaceae) extract has been studied on two different cell types, A-431 cells (epidermal carcinomoid cells) and 3T3 fibroblast cells. It was observed that a fraction of Rubia cordifolia significantly inhibited the incorporation of [ 3 H]-thymidine, induced by fetal bovine serum, in a dose-dependent manner. It also inhibited the PMA (phorbol 12-myristate 13-acetate) induced expression of c-fos genes in A-431 cells. It appears that inhibition of DNA synthesis underlies the mechanism for its antiproliferative properties.

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