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Rubescensins S and T: Seco-ent-Kaurane Diterpenoids from Isodon rubescens var. taihangensis

✍ Scribed by Quan-Bin Han; Rong-Tao Li; Ji-Xia Zhang; Han-Dong Sun

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
112 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new diterpenoids, rubescensin S (=(1__α__,6__β__,14__β__)‐7__α__,20‐epoxy‐1,7,14‐trihydroxy‐16‐oxo‐15,16‐seco‐ent‐kauran‐6,15‐olide; 1) and rubescensin T (=(1__α__,6__β__,11__β__,20__S__)‐7__α__,20‐epoxy‐1,6,7‐trihydroxy‐20‐methoxy‐8,15‐seco‐ent‐kaur‐16‐en‐11,15‐olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16‐seco‐ent‐kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.

📜 SIMILAR VOLUMES

A Novel Asymmetric ent-Kaurane Dimer fro
A Novel Asymmetric ent-Kaurane Dimer from Isodon rubescens var. rubescens
✍ Quan-Bin Han; Zhen-Dan He; Chun-Feng Qiao; Hong-Xi Xu; Han-Dong Sun 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 77 KB

## Abstract A novel asymmetric __ent__‐kaurane dimer, xindongnin P (**1**), was isolated from __Isodon rubescens__ var. __rubescens.__ Its structure was elucidated by detailed spectroscopic analysis. Compound **1** contains a tetrahydrofuran moiety whose formation leads to inversion of configuratio