✦ LIBER ✦
Ru-(Phosphine-Oxazoline) Complexes as Effective, Industrially Viable Catalysts for the Enantioselective Hydrogenation of Aryl Ketones
✍ Scribed by Frédéric Naud; Christophe Malan; Felix Spindler; Carsten Rüggeberg; Andreas T. Schmidt; Hans-Ulrich Blaser
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 128 KB
- Volume
- 348
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
Complexes prepared in situ from RuCl~2~(PPh~3~)~3~ and chiral phosphine‐oxazoline ligands are effective catalysts for the hydrogenation of various aryl ketones with ees up to 99% and substrate to catalyst ratios of 10,000–50,000; the reaction tolerates high substrate concentrations and a pilot process has been developed for the hydrogenation of 3,5‐bistrifluoromethyl acetophenone.