Intracellular Cell Signaling Is A Well Understood Process. However, Extracellular Signals Such As Hormones, Adipokines, Cytokines And Neurotransmitters Are Just As Important But Have Been Largely Ignored In Other Works. They Are Causative Agents For Diseases Including Hypertension, Diabetes, Heart Disease, And Arthritis So Offer New, And Often More Approachable, Targets For Drug Design. Aimed At Medical Professionals And Pharmaceutical Specialists, This Book Integrates Extracellular And Intracellular Signalling Processes And Offers A Fresh Perspective On New Drug Targets. Written By Colleagues At The Same Institution, But With Contributions From Leading International Authorities, It Is The Result Of Close Cooperation Between The Authors Of Different Chapters. Readers Are Introduced To A New Approach To Disease Causation By Adipokines And Toxic Lipids. Heart Disease, Migraines, Stroke, Alzheimer's Disease, Diabetes, Cancer, And Arthritis Are Approached From The Perspective Of Prevention And Treatment By Alteration Of Extracellular Signalling. Evidence Is Presented That The Avoidance Of Toxic Lifestyles Can Reduce The Incidence Of Such Illnesses And New Therapeutic Targets Involving Adipokines, Ceramide And Endocannabinoids Are Discussed. Extracellular And Intracellular Signaling : A New Approach To Diseases And Treatments / James David Adams, Jr., Eric J. Lien, Keith Parker -- Autocrine Effects In White Adipose Tissue And Pancreatic Islets : Emergent Roles In The Regulation Of Adipocyte And Pancreatic B-cell Function / Mary C. Sugden, Mark J. Holness -- One Receptor For Multiple Pathways : Focus On Leptin Signaling / Rodolfo Gomez [and Others] -- Cell Signaling Mechanisms Underlying The Cardiac Actions Of Adipokines / Morris Karmazyn, Venkatesh Rajapurohitam -- Regulation Of Muscle Proteostasis Via Extramuscular Signals / Philip J. Atherton, Nathaniel J. Szewczyk -- Contact Normalization : Mechanisms And Pathways To Biomarkers And Chemotherapeutic Targets / Jhon Alberto Ochoa-alvarez [and Others] -- Involvement Of Adipokines In Migraine Headache / Keith K. Parker -- Adipokines And Alzheimer's Disease / Maria Angela Sortino, Sara Merlo, Simona Spampinato -- Astrocyte Signaling In Neurological Disorders / A.r. Jayakumar, M.d. Norenberg -- Dna, Nuclear Cell Signaling And Neurodegeneration / James D. Adams, Jr. -- G Protein-coupled Receptors : Conformational Gatekeepers Of Transmembrane Signal Transduction And Diversification / Ravinder Abrol, William A. Goddard Iii -- Phytochemicals As Modulators Of Signaling In Inflammation / Lori Klaidman -- Intracellular Signaling Pathways In Parkinson's Disease / Monica Sanchez Contreras, Fernando Cardozo-pelaez. Edited By James D. Adams Jr., Keith K. Parker. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.