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Rp 60180, a new phenothiazine with high affinity for opiate kappa binding sites in animal and human brain

✍ Scribed by V. Fardin; A. Jolly; O. Flamand; A. Carruette; P.-M. Laduron; C. Garret

Book ID: 115885711
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 117 KB
Volume: 183
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(90)93890-3

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## Abstract [^3^H]TCP, an analog of the dissociative anesthetic phencyclidine (PCP), binds with high affinity to two sites in guinea pig brain membranes, one that is MK‐801 sensitive and one that is not. The MK‐801‐sensitive site (PCP site 1) is associated with NMDA receptors, whereas the MK‐801‐in