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Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation

✍ Scribed by Schneider, C.; Porter, N. A.; Brash, A. R.

Book ID
115485503
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2008
Tongue
English
Weight
404 KB
Volume
283
Category
Article
ISSN
0021-9258

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## Abstract ## Objective The lipid peroxidation product 4‐hydroxynonenal (HNE) is prominently produced in osteoarthritic (OA) synovial cells, but its specific contribution to cartilage destruction is not understood. This study was designed to test whether HNE signaling and binding are involved in