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Room temperature facile synthesis of quinoxalines catalyzed by amidosulfonic acid

✍ Scribed by Zhenjiang Li; Weisi Li; Yingjie Sun; He Huang; Pingkai Ouyang


Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
244 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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Amidosulfonic acid NH~2~–SO~3~H catalyzed direct condensations of o‐phenylenediamines with α‐diketones at room temperature in organic solvents to afford quinoxalines in excellent yields. The amidosulfonic acid as a solid acid catalyst in this preparation was efficient and recoverable.


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## Abstract A simple, efficient, and general method has been developed for the one‐pot, three‐component synthesis of α‐aminophosphonates from a condensation reaction of trimethyl phosphite, aldehydes, and amines in the presence of catalytic amount of boric acid (10 mol%) under solvent‐free conditio