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Rolipram, a specific type-4 phosphodiesterase inhibitor, inhibits cyclophosphamide-induced haemorrhagic cystitis in rats

✍ Scribed by Mizuaki Sakura; Hitoshi Masuda; Yoh Matsuoka; Minato Yokoyama; Satoru Kawakami; Kazunori Kihara

Book ID: 109054293
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 358 KB
Volume: 103
Category: Article
ISSN: 1464-4096
DOI: 10.1111/j.1464-410x.2008.07948.x

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SUMMARY: Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used extensively in preclin