Roles of the transforming growth factor β1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: Results of an immunohistochemical study

✍ Scribed by Takanami, Iwao; Tanaka, Fumihiko; Hashizume, Toshinori; Kodaira, Susumu

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 341 KB
• Volume: 64
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199704)64:4<262::aid-jso3>3.0.co;2-7

✦ Synopsis

Background:

In the united states, pulmonary adenocarcinomas have recently replaced squamous cell carcinomas as the most frequent type of lung cancer encountered. the incidence of pulmonary adenocarcinoma continued to increase worldwide.

Method:

To determine the roles of the transforming growth factor-beta 1 (tgf-beta 1), and tgf-beta type i receptor (t beta r-i), and the tgf-beta type ii receptor (t beta r-ii) in the progression of a pulmonary adenocarcinoma, their respective expressions have been immunohistologically studied in specimens from 120 pulmonary adenocarcinoma patients.

Result:

The overall prognosis was significantly poorer for patients showing positive tgf-beta 1, t beta r-i, t beta r-ii expressions than for patients who were negative to all three immunostainings (p < 0.01). our multivariate analysis also revealed that a positive tgf-beta 1 response significantly affect prognosis (p < 0.05).

Conclusions:

Tgf-beta 1, t beta r-i, and t beta r-ii play important roles in tumor progression, and a positive tgf-beta 1 expression can serve as a pulmonary adenocarcinoma marker. t beta r-i and t beta r-ii expressions are necessary for tgf-beta signal transduction.