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Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis

✍ Scribed by Iadevaia, Valentina; Huo, Yilin; Zhang, Ze; Foster, Leonard J.; Proud, Christopher G.

Book ID: 120073843
Publisher: Portland Press
Year: 2012
Tongue: English
Weight: 204 KB
Volume: 40
Category: Article
ISSN: 0300-5127
DOI: 10.1042/BST20110682

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## Abstract Mammalian target of rapamycin (mTOR) mediates a signaling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth rate, participating to a versatile checkpoint that inspects the energy status of the cell. The pathway is activa