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Roles of short chain L-3-hydroxyacyl-COA dehydrogenase in the pathogenesis of Alzheimer's disease

✍ Scribed by Song-Yu Yang; Xue-Ying He; Hortst Schulz; Ying-Zi Yang


Book ID
117411621
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
184 KB
Volume
21
Category
Article
ISSN
0197-4580

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The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) impairs mitochondrial respiration and damages dopaminergic neurons as seen in Parkinson's disease (PD). Here, we report that L-3-hydroxyacyl-CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondr