## Abstract A physiological concentration of extracellular ATP stimulated biphasic Ca^2+^ signal, and the Ca^2+^ transient was decreased and the Ca^2+^ sustain was eliminated immediately after removal of ATP and Ca^2+^ in RBAβ2 astrocytes. Reintroduction of Ca^2+^ induced Ca^2+^ sustain. Stimulatio
Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2
β Scribed by Amos C. Hung; You-Jing Chu; Ya-Hui Lin; Ju-Yun Weng; Hammer B. Chen; Yin-Chung Au; Synthia H. Sun
- Book ID
- 113527772
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 483 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0898-6568
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## Abstract ATP is the dominant messenger for astrocyteβtoβastrocyte calciumβmediated communication. Definition of the exact ATP/P2 receptors in astrocytes and of their coupling to intracellular calcium ([Ca^2+^]~i~) has important implications for brain physiology and pathology. We show that, with
ATP is an important signaling molecule in the nervous system and it's signaling is mediated through the metabotropic P2Y and ionotropic P2X receptors. ATP is known to stimulate Ca 2Ο© influx and phospholipase D (PLD) activity in the type-2 astrocyte cell line, RBA-2; in this study, we show that the r