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Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid

โœ Scribed by Hiroshi Ochi; Ikuo Morita; Sei-itsu Murota

Book ID
115709337
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
640 KB
Volume
294
Category
Article
ISSN
0003-9861

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i