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Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse

✍ Scribed by Yuko Otsuka; Tomoaki Tanaka; Daigaku Uchida; Yoshihiko Noguchi; Naokatsu Saeki; Yasushi Saito; Ichiro Tatsuno


Book ID
116766774
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
212 KB
Volume
365
Category
Article
ISSN
0304-3940

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Regulation of cyclin-dependent kinase 5
✍ Jong-Hee Lee; Kyong-Tai Kim πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 572 KB

## Abstract DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA