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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage

โœ Scribed by Kaneider, Nicole C; Leger, Andrew J; Agarwal, Anika; Nguyen, Nga; Perides, George; Derian, Claudia; Covic, Lidija; Kuliopulos, Athan


Book ID
109923424
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
640 KB
Volume
8
Category
Article
ISSN
1529-2908

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Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment. There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify gene