Role of β2-adrenoceptors (ß-AR), but not ß1-, β3-AR and endothelial nitric oxide, in β-AR-mediated relaxation of rat intrapulmonary artery

ERK1/2 and JNKs, but not p38 kinase, are

ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1β in adult rat cardiac fibroblasts

✍ Zhonglin Xie; Mahipal Singh; Krishna Singh 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB

## Abstract Osteopontin (OPN), also called cytokine Eta‐1, expressed in the myocardium co‐incident with heart failure plays an important role in post myocardial infarction (MI) remodeling by promoting collagen synthesis and accumulation. Angiotensin II (Ang II) and inflammatory cytokines are increa