Role of viruses in the loss of tolerance to self-antigens and in autoimmune diseases
β Scribed by Matthias G. von Herrath; Michael B.A. Oldstone
- Book ID
- 117679682
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 979 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0966-842X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Nuclear factor kB (NF-kB) is a family of structurally related transcription factors. In mammals, the NF-kB family consists of five members: NF-kB1 (p105/50), NF-kB2 (p100/52), RelA (p65), RelB and c-Rel. They all have a structurally conserved N-terminal 300-amino-acid Rel homology domain (RHD), whic
## Abstract Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organβspecific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissueβrestricted selfβantigens (TRA) in medullary thymic epithelial cells (mTEC), wh