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Role of transferrin in uptake of non-physiological metals into cells

✍ Scribed by Felicitas Planas-Bohene; David M. Taylor; John R. Duffield; Gholamreza Darai

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 203 KB
Volume: 1
Category: Article
ISSN: 0263-6484
DOI: 10.1002/cbf.290010303

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✦ Synopsis

A t physiolo ical concentrations of citrate the uptake of 59Fe, 6fGa, and 239Pu into human type B lymphocytes of splenic origin is the same in viable and in non-viable cells. Addition of transferrin has no effect on the uptake into non-viable cells but in viable cells it increases the uptake of Fe and Ga but decreases that of Pu. Uptake decreases as transferrin concentration increases although this is less marked with Ga.

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